You might get error like this
[ERROR] Incorrect definition of table mysql.event: expected column 'sql_mode' at position 14 to have type set('REAL_AS_FLOAT','PIPES_AS_CONCAT','ANSI_QUOTES','IGNORE_SPACE','IGNORE_BAD_TABLE_OPTIONS','ONLY_FULL_GROUP_BY','NO_UNSIGNED_SUBTRACTION','NO_DIR_IN_CREATE','POSTGRESQL','ORACLE','MSSQL','DB2','MAXDB','NO_KEY_OPTIONS','NO_TABLE_OPTIONS','NO_FIELD_OPTIONS','MYSQL323','MYSQL40','ANSI','NO_AUTO_VALUE_ON_ZERO','NO_BACKSLASH_ESCAPES','STRICT_TRANS_TABLES','STRICT_ALL_TABLES','NO_ZERO_IN_DATE','NO_ZERO_DATE','INVALID_DATES','ERROR_FOR_DIVISION_BY_ZERO','TRADITIONAL','NO_AUTO_CREATE_USER','HIGH_NOT_PRECEDENCE','NO_ENGINE_SUBSTITUTION','PAD_CHAR_TO_FULL_LENGTH'), found type set('REAL_AS_FLOAT','PIPES_AS_CONCAT','ANSI_QUOTES','IGNORE_SPACE','NOT_USED','ONLY_FULL_GROUP_BY','NO_UNSIGNED_SUBTRACTION','NO_DIR_IN_CREATE','POSTGRESQL','ORACLE','MSSQL','DB2','MAXDB','NO_KEY_OPTIONS','NO_TABLE_OPTIONS','NO_FIELD_OPTIONS','MYSQL323','MYSQL40','ANSI','NO_AUTO_VALUE_ON_ZERO','NO_BACKSLASH_ESCAPES','STRICT_TRANS_TABLES','STRICT_A
2021-04-30 1:42:07 140285079196800 [ERROR] mysqld: Event Scheduler: An error occurred when initializing system tables. Disabling the Event Scheduler.
Fix by starting the database with –skip-grant-tables options
mysqld --skip-grant-tables
Open new terminal window and run
mysql_upgrade -u root -p
This should upgrade the tables and you can try starting the DB with systemctl command again.
However you might run into this issue.