Create a file with the following contents. Let's call it RCFILE (use the name you want).

source /etc/bash.bashrc
source /home/USER/.bashrc
source /path/to/env/bin/activate

(Replace USER with your username of course.)

Set up a profile with the following settings:

Command: /bin/bash –rcfile /path/to/RCFILE

In the profile manager, on the line of the profile, double-click the Shortcut column, and define a shortcut for that profile.

Now, when you use the shortcut, a new tab will be launched, the command will be run, and the shell will be correctly initialized.

• KDE Neon 20.04

• KDE Neon setup

• https://www.reddit.com/r/kde/comments/mtgf1d/how_to_use_konsole_profile_in_python_virtual/